Cancer Chemotherapy: A Review Update of the Mechanisms of Actions, Prospects and Associated Problems
BIOMED Natural and Applied Science, 2021,1(1);1-19
- Author(s): Aishatu Mustapha, Abdulfatai Ismail, Shehu U. Abdullahi, Opeyemi N. Hassan, Peter I Ugwunnaji, and Eustace B. Berinyuy
- March 21, 2021
- Keywords - Cancer chemotherapy, cancer stem cells mechanisms of action, prospects side effects
Abstract
Cancer is one of the leading causes of death in developed countries, responsible for about 25% of all deaths. On a yearly basis, 0.5% of the population is diagnosed with cancer. Treatment options include surgery, radiotherapy, and systemic therapies such as chemotherapy, endocrine therapy, and targeted agents. Conventional chemotherapeutical agents act by creating toxic effects on all dividing cells. The toxic by-products of some chemotherapeutic drugs are deposited mainly in the liver producing hepatotoxicity, leading to many side-effects like loss of appetite, nausea, vomiting, diarrhea, abdominal cramps and constipation, anemia, fatigue, hyperthermia, loss of hair, etc. In this review update, the benefits and problems of chemotherapy have been highlighted and the mechanisms involved in cancer formation, groups of chemotherapeutic agents, as well as method of chemotherapeutic administration, have been discussed.
Corresponding Author(s)
Corresponding author*:
Dr. Eustace B. Berinyuy
Faculty of Medicine and Biomedical Science, University of Yaoundé 1, Cameroon
Citations
Mustapha, A., Ismail, A., Abdullahi S.U., Hassan, O.N., Ugwunnaji, P.I. and Berinyu, E.B. (2021). Cancer Chemotherapy; A review update of the mechanisms of action, prospects and associated problems. BIOMED Natural and Applied Science. 01(01), 001–017
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